RT Journal Article SR Electronic T1 Visualization of Brown Adipose Tissue with 99mTc-Methoxyisobutylisonitrile on SPECT/CT JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 752 OP 756 DO 10.2967/jnumed.107.048074 VO 49 IS 5 A1 Sibyll Goetze A1 William C. Lavely A1 Harvey A. Ziessman A1 Richard L. Wahl YR 2008 UL http://jnm.snmjournals.org/content/49/5/752.abstract AB Brown adipose tissue (BAT) is retained into adulthood in some patients. It has been imaged using several radiopharmaceuticals, including 18F-FDG. Using SPECT/CT, we assessed whether and how frequently uptake of 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) was present in expected locations of BAT. Methods: A total of 205 SPECT/CT scans using 99mTc-MIBI for parathyroid imaging were reviewed for the presence of 99mTc-MIBI uptake in expected locations of BAT. Results: We detected 99mTc-MIBI uptake in BAT in 13 of 205 patients (6.3%). When BAT was visualized, it was detected on both early and delayed scans. The patients with 99mTc-MIBI uptake in BAT were younger than the patients with no 99mTc-MIBI uptake (P = 0.044). Conclusion: Uptake of 99mTc-MIBI in BAT is relatively common in this adult patient population and should not be confused with 99mTc-MIBI-avid–tumors. SPECT/CT can be useful for defining such tracer uptake as a normal physiologic variant.