RT Journal Article SR Electronic T1 18F-FDG PET/CT for Image-Guided and Intensity-Modulated Radiotherapy JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1655 OP 1665 DO 10.2967/jnumed.108.055780 VO 50 IS 10 A1 Eric C. Ford A1 Joseph Herman A1 Ellen Yorke A1 Richard L. Wahl YR 2009 UL http://jnm.snmjournals.org/content/50/10/1655.abstract AB Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and neck cancer, and pancreatic adenocarcinoma. This review focuses on the use of 18F-FDG PET/CT to aid in planning radiotherapy and the associated benefits and challenges. We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning.