TY - JOUR T1 - <sup>18</sup>F-FDG PET/CT for Image-Guided and Intensity-Modulated Radiotherapy JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1655 LP - 1665 DO - 10.2967/jnumed.108.055780 VL - 50 IS - 10 AU - Eric C. Ford AU - Joseph Herman AU - Ellen Yorke AU - Richard L. Wahl Y1 - 2009/10/01 UR - http://jnm.snmjournals.org/content/50/10/1655.abstract N2 - Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and neck cancer, and pancreatic adenocarcinoma. This review focuses on the use of 18F-FDG PET/CT to aid in planning radiotherapy and the associated benefits and challenges. We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning. ER -