PT  - JOURNAL ARTICLE
AU  - Eric C. Ford
AU  - Joseph Herman
AU  - Ellen Yorke
AU  - Richard L. Wahl
TI  - <sup>18</sup>F-FDG PET/CT for Image-Guided and Intensity-Modulated Radiotherapy
AID  - 10.2967/jnumed.108.055780
DP  - 2009 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1655--1665
VI  - 50
IP  - 10
4099  - http://jnm.snmjournals.org/content/50/10/1655.short
4100  - http://jnm.snmjournals.org/content/50/10/1655.full
SO  - J Nucl Med2009 Oct 01; 50
AB  - Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and neck cancer, and pancreatic adenocarcinoma. This review focuses on the use of 18F-FDG PET/CT to aid in planning radiotherapy and the associated benefits and challenges. We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning.