%0 Journal Article %A Eric C. Ford %A Joseph Herman %A Ellen Yorke %A Richard L. Wahl %T 18F-FDG PET/CT for Image-Guided and Intensity-Modulated Radiotherapy %D 2009 %R 10.2967/jnumed.108.055780 %J Journal of Nuclear Medicine %P 1655-1665 %V 50 %N 10 %X Advances in technology have allowed extremely precise control of radiation dose delivery and localization within a patient. The ability to confidently delineate target tumor boundaries, however, has lagged behind. 18F-FDG PET/CT, with its ability to distinguish metabolically active disease from normal tissue, may provide a partial solution to this problem. Here we review the current applications of 18F-FDG PET/CT in a variety of disease sites, including non–small cell lung cancer, head and neck cancer, and pancreatic adenocarcinoma. This review focuses on the use of 18F-FDG PET/CT to aid in planning radiotherapy and the associated benefits and challenges. We also briefly consider novel radiopharmaceuticals that are beginning to be used in the context of radiotherapy planning. %U https://jnm.snmjournals.org/content/jnumed/50/10/1655.full.pdf