TY - JOUR T1 - Functional Images Reflect Aggressiveness of Endometrial Carcinoma: Estrogen Receptor Expression Combined with <sup>18</sup>F-FDG PET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1598 LP - 1604 DO - 10.2967/jnumed.108.060145 VL - 50 IS - 10 AU - Tetsuya Tsujikawa AU - Yoshio Yoshida AU - Takashi Kudo AU - Yasushi Kiyono AU - Tetsuji Kurokawa AU - Masato Kobayashi AU - Tatsuro Tsuchida AU - Yasuhisa Fujibayashi AU - Fumikazu Kotsuji AU - Hidehiko Okazawa Y1 - 2009/10/01 UR - http://jnm.snmjournals.org/content/50/10/1598.abstract N2 - The grade of histologic differentiation is one of the most important prognostic factors in patients with endometrial carcinoma and postoperative staging. The aim of this study was to investigate whether 16α-18F-fluoro-17β-estradiol (18F-FES) and 18F-FDG PET reflect clinicopathologic features in patients with endometrial tumors. Methods: A total of 22 patients with endometrial adenocarcinoma and 9 with endometrial hyperplasia (mean age, 56.0 ± 15.3 y) underwent 18F-FES PET for estrogen receptor imaging and 18F-FDG PET. Regional values of tracer uptake were evaluated using standardized uptake value (SUV) and the SUV ratio of 18F-FDG to 18F-FES. The accuracy for predicting tumor aggressiveness defined as high-risk carcinoma (International Federation of Gynecology and Obstetrics [FIGO] stage ≥ Ic or histologic grade ≥ 2), low-risk carcinoma (FIGO stage ≤ Ib and grade 1), and hyperplasia was compared for each PET parameter using receiver-operating-characteristic (ROC) analysis. The diagnostic accuracy of MRI findings for clinical staging was also compared. Results: Although the SUV for 18F-FDG was significantly lower in endometrial hyperplasia than in carcinoma, a significant difference between high-risk and low-risk carcinoma was observed only in SUV for 18F-FES. High-risk carcinoma showed a significantly greater 18F-FDG–to–18F-FES ratio (3.6 ± 2.1) than did low-risk carcinoma (1.3 ± 0.5, P &lt; 0.01) and hyperplasia (0.3 ± 0.1, P &lt; 0.005). Low-risk carcinoma showed a significantly higher 18F-FDG–to–18F-FES ratio than hyperplasia (P &lt; 0.0001). In ROC analysis, the most accurate diagnostic PET parameter for predicting high-risk and low-risk carcinoma was the 18F-FDG–to–18F-FES ratio. The optimal 18F-FDG/18F-FES cutoff value of 2.0, determined by ROC analysis, revealed 73% sensitivity, 100% specificity, and 86% accuracy, which was better than the 77% accuracy for MRI. The 18F-FDG–to–18F-FES ratio of 0.5 yielded a correct diagnosis for carcinoma from hyperplasia with 100% accuracy. Conclusion: Endometrial carcinoma reduces estrogen dependency with accelerated glucose metabolism as it progresses to a higher stage or grade. 18F-FES and 18F-FDG PET studies provide a new index of the 18F-FDG–to–18F-FES ratio, which is considered the most informative index reflecting tumor aggressiveness. This index will be useful for making noninvasive diagnoses and deciding the appropriate therapeutic strategy for patients with endometrial carcinoma. ER -