RT Journal Article
SR Electronic
T1 Tumor Cell Metabolism Imaging
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 43S
OP 63S
DO 10.2967/jnumed.107.045930
VO 49
IS Suppl 2
A1 Christian Plathow
A1 Wolfgang A. Weber
YR 2008
UL http://jnm.snmjournals.org/content/49/Suppl_2/43S.abstract
AB Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.