RT Journal Article
SR Electronic
T1 Accelerating the Development of Novel Molecular Imaging Probes: A Role for High-Throughput Screening
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1401
OP 1404
DO 10.2967/jnumed.108.053009
VO 49
IS 9
A1 H. Charles Manning
A1 Adam Lander
A1 Eliot McKinley
A1 Nathan J. Mutic
YR 2008
UL http://jnm.snmjournals.org/content/49/9/1401.abstract
AB Molecular imaging is a rapidly emerging research tool and clinical discipline aimed at noninvasive, quantitative visualization of in vivo molecular processes occurring at cellular and subcellular levels. At present, advancement of the molecular imaging field is driven by the development of improved imaging hardware for use in preclinical and clinical settings, the identification and validation of new, biologically relevant imaging targets, and the development of improved imaging probes derived from novel chemistries. Of these 3 essential facets, which comprise a majority of current molecular imaging research, hardware development and novel target discovery significantly outpace the development and clinical advancement of new molecular imaging probes, particularly with respect to cancer imaging.