TY - JOUR T1 - SPECT/CT JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1305 LP - 1319 DO - 10.2967/jnumed.107.050195 VL - 49 IS - 8 AU - Andreas K. Buck AU - Stephan Nekolla AU - Sibylle Ziegler AU - Ambros Beer AU - Bernd J. Krause AU - Ken Herrmann AU - Klemens Scheidhauer AU - Hans-Juergen Wester AU - Ernst J. Rummeny AU - Markus Schwaiger AU - Alexander Drzezga Y1 - 2008/08/01 UR - http://jnm.snmjournals.org/content/49/8/1305.abstract N2 - In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications. ER -