PT  - JOURNAL ARTICLE
AU  - Yasuyuki Suzuki
AU  - Piotr J. Slomka
AU  - Arik Wolak
AU  - Muneo Ohba
AU  - Shoji Suzuki
AU  - Ling De Yang
AU  - Guido Germano
AU  - Daniel S. Berman
TI  - Motion-Frozen Myocardial Perfusion SPECT Improves Detection of Coronary Artery Disease in Obese Patients
AID  - 10.2967/jnumed.108.050997
DP  - 2008 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1075--1079
VI  - 49
IP  - 7
4099  - http://jnm.snmjournals.org/content/49/7/1075.short
4100  - http://jnm.snmjournals.org/content/49/7/1075.full
SO  - J Nucl Med2008 Jul 01; 49
AB  - In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1–46.8, average, 34.3 ± 3.6; age, 63 ± 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3 mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.