TY - JOUR T1 - Role of <sup>99m</sup>Tc-Octreotide Acetate Scintigraphy in Suspected Lung Cancer Compared with <sup>18</sup>F-FDG Dual-Head Coincidence Imaging JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1442 LP - 1448 DO - 10.2967/jnumed.107.040824 VL - 48 IS - 9 AU - Feng Wang AU - Zizheng Wang AU - Weixuan Yao AU - Hong Xie AU - Jie Xu AU - Li Tian Y1 - 2007/09/01 UR - http://jnm.snmjournals.org/content/48/9/1442.abstract N2 - The aim of this study was to evaluate the clinical value of tomographic 99mTc-octreotide acetate (hereafter, 99mTc-octreotide) scintigraphy in the detection of patients with suspected lung cancer in comparison with that of 18F-FDG dual-head coincidence imaging (DHC). Methods: Forty-four consecutive patients with suspected pulmonary neoplasms underwent tomographic 99mTc-octreotide scintigraphy and 18F-FDG coincidence imaging using the same gantry. The region of interest was drawn on the entire primary lesion. The tumor-to-normal tissue tracer values for both 99mTc-octreotide and 18F-FDG were determined using region of interests and expressed as T/Nr and T/Nm, respectively. Final diagnosis was confirmed by histopathologic analysis or clinical follow-up. Results: Thirty-one of the 44 patients had lung cancer—6 with small cell lung cancer (SCLC) and 25 with non–small cell lung cancer (NSCLC). Thirteen of the 44 patients had benign lung lesions. The sensitivity, specificity, positive predictive value, and negative predictive value of 99mTc-octreotide were 100%, 75.7%, 90.1%, and 100%, respectively, and of 18F-FDG DHC were 100%, 46.1%, 83.8%, and 100%, respectively. In the 31 patients with malignant tumors, all 38 abnormal lymph nodes in 20 patients showed abnormal high focal uptake of 18F-FDG; only 7 patients with 10 regional lymph adenopathies showed moderate uptake of 99mTc-octreotide. Thirteen patients with 39 distant sites of abnormal uptake visualized (imaging stage IV) with 99mTc-octreotide included 2 patients with brain metastases, 6 patients with pleural invasion and multiple bone metastasis, 2 patients with contralateral internal lung metastasis and pleural invasion, and 3 patients with only multiple bone metastasis. The final diagnosis was confirmed by histopathology or clinical follow-up. Conclusion: The sensitivity of 99mTc-octreotide for the detection of lung cancer at the primary lesion was comparable with that of 18F-FDG coincidence imaging. Tomographic 99mTc-octreotide scintigraphy had lower sensitivity for the detection of hilar and mediastinal lymph node metastasis compared with that of 18F-FDG coincidence PET, but it had high sensitivity for the detection of remote metastatic lesions. However, because of the small population, further investigation is necessary. ER -