RT Journal Article SR Electronic T1 Recommendations on the Use of 18F-FDG PET in Oncology JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 480 OP 508 DO 10.2967/jnumed.107.047787 VO 49 IS 3 A1 James W. Fletcher A1 Benjamin Djulbegovic A1 Heloisa P. Soares A1 Barry A. Siegel A1 Val J. Lowe A1 Gary H. Lyman A1 R. Edward Coleman A1 Richard Wahl A1 John Christopher Paschold A1 Norbert Avril A1 Lawrence H. Einhorn A1 W. Warren Suh A1 David Samson A1 Dominique Delbeke A1 Mark Gorman A1 Anthony F. Shields YR 2008 UL http://jnm.snmjournals.org/content/49/3/480.abstract AB The rationale was to develop recommendations on the use of 18F-FDG PET in breast, colorectal, esophageal, head and neck, lung, pancreatic, and thyroid cancer; lymphoma, melanoma, and sarcoma; and unknown primary tumor. Outcomes of interest included the use of 18F-FDG PET for diagnosing, staging, and detecting the recurrence or progression of cancer. Methods: A search was performed to identify all published randomized controlled trials and systematic reviews in the literature. An additional search was performed to identify relevant unpublished systematic reviews. These publications comprised both retrospective and prospective studies of varied methodologic quality. The anticipated consequences of false-positive and false-negative tests when evaluating clinical usefulness, and the impact of 18F-FDG PET on the management of cancer patients, were also reviewed. Results and Conclusion: 18F-FDG PET should be used as an imaging tool additional to conventional radiologic methods such as CT or MRI; any positive finding that could lead to a clinically significant change in patient management should be confirmed by subsequent histopathologic examination because of the risk of false-positive results. 18F-FDG PET should be used in the appropriate clinical setting for the diagnosis of head and neck, lung, or pancreatic cancer and for unknown primary tumor. PET is also indicated for staging of breast, colon, esophageal, head and neck, and lung cancer and of lymphoma and melanoma. In addition, 18F-FDG PET should be used to detect recurrence of breast, colorectal, head and neck, or thyroid cancer and of lymphoma.