PT  - JOURNAL ARTICLE
AU  - James W. Fletcher
AU  - Benjamin Djulbegovic
AU  - Heloisa P. Soares
AU  - Barry A. Siegel
AU  - Val J. Lowe
AU  - Gary H. Lyman
AU  - R. Edward Coleman
AU  - Richard Wahl
AU  - John Christopher Paschold
AU  - Norbert Avril
AU  - Lawrence H. Einhorn
AU  - W. Warren Suh
AU  - David Samson
AU  - Dominique Delbeke
AU  - Mark Gorman
AU  - Anthony F. Shields
TI  - Recommendations on the Use of <sup>18</sup>F-FDG PET in Oncology
AID  - 10.2967/jnumed.107.047787
DP  - 2008 Mar 01
TA  - Journal of Nuclear Medicine
PG  - 480--508
VI  - 49
IP  - 3
4099  - http://jnm.snmjournals.org/content/49/3/480.short
4100  - http://jnm.snmjournals.org/content/49/3/480.full
SO  - J Nucl Med2008 Mar 01; 49
AB  - The rationale was to develop recommendations on the use of 18F-FDG PET in breast, colorectal, esophageal, head and neck, lung, pancreatic, and thyroid cancer; lymphoma, melanoma, and sarcoma; and unknown primary tumor. Outcomes of interest included the use of 18F-FDG PET for diagnosing, staging, and detecting the recurrence or progression of cancer. Methods: A search was performed to identify all published randomized controlled trials and systematic reviews in the literature. An additional search was performed to identify relevant unpublished systematic reviews. These publications comprised both retrospective and prospective studies of varied methodologic quality. The anticipated consequences of false-positive and false-negative tests when evaluating clinical usefulness, and the impact of 18F-FDG PET on the management of cancer patients, were also reviewed. Results and Conclusion: 18F-FDG PET should be used as an imaging tool additional to conventional radiologic methods such as CT or MRI; any positive finding that could lead to a clinically significant change in patient management should be confirmed by subsequent histopathologic examination because of the risk of false-positive results. 18F-FDG PET should be used in the appropriate clinical setting for the diagnosis of head and neck, lung, or pancreatic cancer and for unknown primary tumor. PET is also indicated for staging of breast, colon, esophageal, head and neck, and lung cancer and of lymphoma and melanoma. In addition, 18F-FDG PET should be used to detect recurrence of breast, colorectal, head and neck, or thyroid cancer and of lymphoma.