TY - JOUR T1 - Multicenter Standardized <sup>18</sup>F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 390 LP - 398 DO - 10.2967/jnumed.107.045385 VL - 49 IS - 3 AU - Lisa Mosconi AU - Wai H. Tsui AU - Karl Herholz AU - Alberto Pupi AU - Alexander Drzezga AU - Giovanni Lucignani AU - Eric M. Reiman AU - Vjera Holthoff AU - Elke Kalbe AU - Sandro Sorbi AU - Janine Diehl-Schmid AU - Robert Perneczky AU - Francesca Clerici AU - Richard Caselli AU - Bettina Beuthien-Baumann AU - Alexander Kurz AU - Satoshi Minoshima AU - Mony J. de Leon Y1 - 2008/03/01 UR - http://jnm.snmjournals.org/content/49/3/390.abstract N2 - This multicenter study examined 18F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI). Methods: We examined the 18F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals (“normals” or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal 18F-FDG uptake that were then applied to characterize MCI. Results: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. 18F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns. Conclusion: Standardized automated analysis of 18F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia. ER -