RT Journal Article
SR Electronic
T1 Multicenter Standardized <sup>18</sup>F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 390
OP 398
DO 10.2967/jnumed.107.045385
VO 49
IS 3
A1 Mosconi, Lisa
A1 Tsui, Wai H.
A1 Herholz, Karl
A1 Pupi, Alberto
A1 Drzezga, Alexander
A1 Lucignani, Giovanni
A1 Reiman, Eric M.
A1 Holthoff, Vjera
A1 Kalbe, Elke
A1 Sorbi, Sandro
A1 Diehl-Schmid, Janine
A1 Perneczky, Robert
A1 Clerici, Francesca
A1 Caselli, Richard
A1 Beuthien-Baumann, Bettina
A1 Kurz, Alexander
A1 Minoshima, Satoshi
A1 de Leon, Mony J.
YR 2008
UL http://jnm.snmjournals.org/content/49/3/390.abstract
AB This multicenter study examined 18F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI). Methods: We examined the 18F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals (“normals” or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal 18F-FDG uptake that were then applied to characterize MCI. Results: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. 18F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns. Conclusion: Standardized automated analysis of 18F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.