RT Journal Article SR Electronic T1 Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 390 OP 398 DO 10.2967/jnumed.107.045385 VO 49 IS 3 A1 Mosconi, Lisa A1 Tsui, Wai H. A1 Herholz, Karl A1 Pupi, Alberto A1 Drzezga, Alexander A1 Lucignani, Giovanni A1 Reiman, Eric M. A1 Holthoff, Vjera A1 Kalbe, Elke A1 Sorbi, Sandro A1 Diehl-Schmid, Janine A1 Perneczky, Robert A1 Clerici, Francesca A1 Caselli, Richard A1 Beuthien-Baumann, Bettina A1 Kurz, Alexander A1 Minoshima, Satoshi A1 de Leon, Mony J. YR 2008 UL http://jnm.snmjournals.org/content/49/3/390.abstract AB This multicenter study examined 18F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI). Methods: We examined the 18F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals (“normals” or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal 18F-FDG uptake that were then applied to characterize MCI. Results: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. 18F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns. Conclusion: Standardized automated analysis of 18F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.