PT  - JOURNAL ARTICLE
AU  - Van de Wiele, Christophe
AU  - Phonteyne, Philippe
AU  - Pauwels, Patrick
AU  - Goethals, Ingeborg
AU  - Van den Broecke, Rudi
AU  - Cocquyt, Veronique
AU  - Dierckx, Rudi Andre
TI  - Gastrin-Releasing Peptide Receptor Imaging in Human Breast Carcinoma Versus Immunohistochemistry
AID  - 10.2967/jnumed.107.047167
DP  - 2008 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 260--264
VI  - 49
IP  - 2
4099  - http://jnm.snmjournals.org/content/49/2/260.short
4100  - http://jnm.snmjournals.org/content/49/2/260.full
SO  - J Nucl Med2008 Feb 01; 49
AB  - This study reports on the uptake of 99mTc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC). Methods: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant bone-mestastasized breast carcinoma underwent 99mTc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive. Results: The uptake of 99mTc-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. 99mTc-RP527 uptake was not found in any of the tamoxifen-resistant patients. Conclusion: Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.