PT - JOURNAL ARTICLE AU - Van de Wiele, Christophe AU - Phonteyne, Philippe AU - Pauwels, Patrick AU - Goethals, Ingeborg AU - Van den Broecke, Rudi AU - Cocquyt, Veronique AU - Dierckx, Rudi Andre TI - Gastrin-Releasing Peptide Receptor Imaging in Human Breast Carcinoma Versus Immunohistochemistry AID - 10.2967/jnumed.107.047167 DP - 2008 Feb 01 TA - Journal of Nuclear Medicine PG - 260--264 VI - 49 IP - 2 4099 - http://jnm.snmjournals.org/content/49/2/260.short 4100 - http://jnm.snmjournals.org/content/49/2/260.full SO - J Nucl Med2008 Feb 01; 49 AB - This study reports on the uptake of 99mTc-RP527 by human breast carcinoma and its relationship to gastrin-releasing peptide receptor (GRP-R) expression as measured by immunohistochemistry (IHC). Methods: Nine patients referred because of a clinical diagnosis suggestive of breast carcinoma and 5 patients with tamoxifen-resistant bone-mestastasized breast carcinoma underwent 99mTc-RP527 scintigraphy. The findings were compared with routine staging examinations in all patients and with routine histology and IHC GRP-R staining in the first 9 patients. All 9 patients with suspected breast lesions were tumor positive. Results: The uptake of 99mTc-RP527 was evident in the primary tumor in 8 of 9 patients and in involved lymph nodes and part of the distant metastasis limited to the bone when present. 99mTc-RP527 uptake was not found in any of the tamoxifen-resistant patients. Conclusion: Uptake by primary breast carcinoma was significantly correlated with the presence of GRP-Rs as assessed by means of IHC.