RT Journal Article
SR Electronic
T1 Novel Tracers and Their Development for the Imaging of Metastatic Prostate Cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 2031
OP 2041
DO 10.2967/jnumed.108.050658
VO 49
IS 12
A1 Andrea B. Apolo
A1 Neeta Pandit-Taskar
A1 Michael J. Morris
YR 2008
UL http://jnm.snmjournals.org/content/49/12/2031.abstract
AB There are presently no accurate methods of imaging prostate cancer metastases to bone. An unprecedented number of novel imaging agents, based on the biology of the disease, are now available for testing. We reviewed contemporary molecular imaging modalities that have been tested in humans with metastatic prostate cancer, with consideration of the studies' adherence to current prostate cancer clinical trial designs. Articles from the years 2002 to 2008 on PET using 18F-FDG, 11C-choline, 18F-choline, 18F-flouride, 11C-acetate, 11C-methionine, and 18F-fluoro-5α-dihydrotestosterone in patients with metastatic prostate cancer were reviewed. Although these studies are encouraging, most focus on the rising population with prostate-specific antigen, and many involve small numbers of patients and do not adhere to consensus criteria for clinical trial designs in prostate cancer. Hence, although many promising agents are available for testing, such studies would benefit from closer collaboration between those in the fields of medical oncology and nuclear medicine.