PT  - JOURNAL ARTICLE
AU  - Janet F. Eary
AU  - Finbarr O'Sullivan
AU  - Janet O'Sullivan
AU  - Ernest U. Conrad
TI  - Spatial Heterogeneity in Sarcoma <sup>18</sup>F-FDG Uptake as a Predictor of Patient Outcome
AID  - 10.2967/jnumed.108.053397
DP  - 2008 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1973--1979
VI  - 49
IP  - 12
4099  - http://jnm.snmjournals.org/content/49/12/1973.short
4100  - http://jnm.snmjournals.org/content/49/12/1973.full
SO  - J Nucl Med2008 Dec 01; 49
AB  - 18F-FDG PET images of tumors often display highly heterogeneous spatial distribution of 18F-FDG–positive pixels. We proposed that this heterogeneity in 18F-FDG spatial distribution can be used to predict tumor biologic aggressiveness. This study presents data to support the hypothesis that a new heterogeneity-analysis algorithm applied to 18F-FDG PET images of tumors in patients is predictive of patient outcome. Methods: 18F-FDG PET images from 238 patients with sarcoma were analyzed using a new algorithm for heterogeneity analysis in tumor 18F-FDG spatial distribution. Patient characteristics, tumor histology, and patient outcome were compared with image analysis results using univariate and multivariate analysis. Cox proportional hazards models were used to further analyze the significance of the data associations. Results: Statistical analyses show that heterogeneity analysis is a strong independent predictor of patient outcome. Conclusion: The new 18F-FDG PET tumor image heterogeneity analysis method is validated for the ability to predict patient outcome in a clinical population of patients with sarcoma. This method can be extended to other PET image datasets in which heterogeneity in tissue uptake of a radiotracer may predict patient outcome.