RT Journal Article
SR Electronic
T1 Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1798
OP 1803
DO 10.2967/jnumed.108.053264
VO 49
IS 11
A1 Eric Guedj
A1 Serge Cammilleri
A1 Jean Niboyet
A1 Patricia Dupont
A1 Eric Vidal
A1 Jean-Pierre Dropinski
A1 Olivier Mundler
YR 2008
UL http://jnm.snmjournals.org/content/49/11/1798.abstract
AB The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia. Methods: We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale), disability (Fibromyalgia Impact Questionnaire [FIQ]), and anxiety and depression status (Hospital Anxiety and Depression scale) in 20 patients with fibromyalgia (P voxel < 0.005). Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients. Results: FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion. FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow. Conclusion: These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.