PT  - JOURNAL ARTICLE
AU  - Maureen M. Henneman
AU  - Ji Chen
AU  - Petra Dibbets-Schneider
AU  - Marcel P. Stokkel
AU  - Gabe B. Bleeker
AU  - Claudia Ypenburg
AU  - Ernst E. van der Wall
AU  - Martin J. Schalij
AU  - Ernest V. Garcia
AU  - Jeroen J. Bax
TI  - Can LV Dyssynchrony as Assessed with Phase Analysis on Gated Myocardial Perfusion SPECT Predict Response to CRT?
AID  - 10.2967/jnumed.107.039925
DP  - 2007 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1104--1111
VI  - 48
IP  - 7
4099  - http://jnm.snmjournals.org/content/48/7/1104.short
4100  - http://jnm.snmjournals.org/content/48/7/1104.full
SO  - J Nucl Med2007 Jul 01; 48
AB  - Cardiac resynchronization therapy (CRT) is now a well-recognized therapeutic option for patients with end-stage heart failure. However, not all patients respond to CRT, and, therefore, preimplantation identification of responders is desirable. The aim of the present study was to investigate whether the degree of left ventricular (LV) dyssynchrony, as assessed with phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which patients will respond to CRT. Methods: Forty-two patients with severe heart failure, depressed LV ejection fraction, and wide QRS complex were prospectively included for implantation of a CRT device and underwent GMPS and 2-dimensional echocardiography as part of the clinical protocol. Clinical status was evaluated using the New York Heart Association (NYHA) classification, 6-min walk test, and quality-of-life score. The histogram bandwidth and phase SD (parameters indicating LV dyssynchrony) were assessed from GMPS, and the clinical status and echocardiographic variables were reassessed at 6-mo follow-up. Results: Responders (71%) and nonresponders (29%) had comparable baseline characteristics, except for histogram bandwidth (175° ± 63° vs. 117° ± 51° [P < 0.01]) and phase SD (56.3° ± 19.9° vs. 37°.1 ± 14.4° [P < 0.01]), which were significantly larger in responders compared with nonresponders. Moreover, receiver-operating-characteristic curve analysis demonstrated an optimal cutoff value of 135° for histogram bandwidth (sensitivity and specificity of 70%) and of 43° for phase SD (sensitivity and specificity of 74%) for the prediction of response to CRT. Conclusion: Response to CRT is related to the presence of LV dyssynchrony assessed by phase analysis with GMPS. A cutoff value of 135° for histogram bandwidth and of 43° for phase SD could be used to predict response to CRT. Larger prospective studies are warranted to confirm the present findings.