PT - JOURNAL ARTICLE AU - Edouard Louis AU - Geoffrey Ancion AU - Arnaud Colard AU - Veronique Spote AU - Jacques Belaiche AU - Roland Hustinx TI - Noninvasive Assessment of Crohn's Disease Intestinal Lesions with <sup>18</sup>F-FDG PET/CT AID - 10.2967/jnumed.107.040436 DP - 2007 Jul 01 TA - Journal of Nuclear Medicine PG - 1053--1059 VI - 48 IP - 7 4099 - http://jnm.snmjournals.org/content/48/7/1053.short 4100 - http://jnm.snmjournals.org/content/48/7/1053.full SO - J Nucl Med2007 Jul 01; 48 AB - Pilot studies have shown good sensitivity and specificity for 18F-FDG PET in detecting gastrointestinal lesions of Crohn's disease. The combination of 18F-FDG PET with CT may further improve the localization and characterization of lesions with increased 18F-FDG uptake. Our aim was to assess the use of 18F-FDG PET/CT in evaluating the activity and location of Crohn's disease along the gastrointestinal tract. Methods: After giving informed consent, 22 patients with Crohn's disease were prospectively studied. They underwent 18F-FDG PET/CT, followed by ileocolonoscopy within 1 wk (mean, 2 d). The Crohn's disease activity index (CDAI) was calculated, and serum C-reactive protein (CRP) and fecal calprotectin were measured before endoscopy. The Crohn's disease endoscopy index of severity (CDEIS) was calculated during endoscopy. The global CDEIS score and endoscopic subscores for various ileocolonic segments were used for analysis. Results: Globally, 95 intestinal and colonic segments in 22 patients were analyzed. 18F-FDG PET/CT detected 35 of 48 endoscopically affected segments (sensitivity for the detection of endoscopic lesions, 72.9%). The sensitivity of 18F-FDG PET/CT for the detection of severe endoscopic lesions (deep ulcers and strictures) was 100% (14/14). The global PET/CT score significantly correlated with CDEIS (r = 0.51; 95% confidence interval [CI], 0.09–0.77; P = 0.017), CDAI (r = 0.58; 95% CI, 0.17–0.80; P = 0.005), and CRP (r = 0.56; 95% CI, 0.19–0.81; P = 0.007). Conclusion: 18F-FDG PET/CT was globally well correlated to the clinical, endoscopic, and biologic activity of Crohn's disease. Above all, this technique had a good sensitivity for the detection of intestinal and colonic segments with moderate to severe mucosal lesions. The potential impact of this promising tool on the global management of patients with Crohn's disease should be further evaluated in prospective studies.