PT - JOURNAL ARTICLE AU - Claude Nahmias AU - Wahid T. Hanna AU - Lindi M. Wahl AU - Misty J. Long AU - Karl F. Hubner AU - David W. Townsend TI - Time Course of Early Response to Chemotherapy in Non–Small Cell Lung Cancer Patients with <sup>18</sup>F-FDG PET/CT AID - 10.2967/jnumed.106.038513 DP - 2007 May 01 TA - Journal of Nuclear Medicine PG - 744--751 VI - 48 IP - 5 4099 - http://jnm.snmjournals.org/content/48/5/744.short 4100 - http://jnm.snmjournals.org/content/48/5/744.full SO - J Nucl Med2007 May 01; 48 AB - PET and 18F-FDG have the potential to follow the early metabolic response to chemotherapy in patients with non–small cell lung cancer and to predict success or failure of the therapy. Methods: We studied 16 patients with non–small cell lung cancer as they followed 2 courses of docetaxel and carboplatin. Each patient was studied weekly for 7 wk, and tissue activity was assessed by the amount of radioactivity retained 90 min after the intravenous injection of 18F-FDG. In a prospective analysis, the linear least-squares method was used to evaluate the time course of metabolic activity in tumor and liver, bone marrow, and unaffected lung tissues; a metabolic response was defined as a response in which the slope of the regression was negative and significantly different from zero. Our hypothesis was that patients who exhibited a tumor metabolic response would survive longer than those who did not. In a retrospective examination of our data, we grouped our patients into those who survived &lt;6 mo and those who survived longer and calculated the difference in the standardized uptake value (SUV) between day 7 and subsequent time points to determine the most appropriate timing of 2 PET studies in predicting response to therapy. Results: Fifteen of 16 patients completed the study. In the prospective study, 8 patients were classified as nonresponders as the slope of the regression of tumor SUV versus time was not different from zero; they all died within 35 wk of the end of their study. Seven patients were classified as responders; 5 survived and 2 died, one at 25 wk and the other at 76 wk. In the retrospective study, a decrease of 0.5 SUV between studies performed at 1 and 3 wk after the initiation of chemotherapy was predictive of those patients who survived &gt;6 mo and in whom chemotherapy was presumably successful. Conclusion: Patients with non–small cell lung cancer who had a positive outcome, as exhibited by prolonged survival, were those who showed a tumor metabolic response assessed using weekly 18F-FDG PET studies. 18F-FDG PET studies performed at 1 and 3 wk after the initiation of chemotherapy allowed prediction of the response to therapy.