TY - JOUR T1 - PET/CT Quantitation of the Effect of Patient-Related Factors on Cardiac <sup>18</sup>F-FDG Uptake JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 234 LP - 239 VL - 48 IS - 2 AU - Ora Israel AU - Michal Weiler-Sagie AU - Shmuel Rispler AU - Rachel Bar-Shalom AU - Alex Frenkel AU - Zohar Keidar AU - Avi Bar-Shalev AU - H. William Strauss Y1 - 2007/02/01 UR - http://jnm.snmjournals.org/content/48/2/234.abstract N2 - The effect of multiple patient-related factors on the degree of cardiac 18F-FDG uptake was assessed. Methods: Five hundred four consecutive patients undergoing routine 18F-FDG PET/CT studies completed a clinical questionnaire. 18F-FDG uptake was measured as the mean standardized uptake value within the heart delineated on the CT component of the study. Univariate and multivariate analyses assessed the influence of 51 clinical factors on cardiac 18F-FDG uptake. Results: On both multivariate and univariate analyses, cardiac 18F-FDG uptake was significantly lower in diabetics and in patients receiving bezafibrate or levothyroxine. Cardiac 18F-FDG uptake was significantly higher in men, patients younger than 30 y old, fasting duration of &lt;5 h, patients with heart failure, and those receiving benzodiazepines. Conclusion: Cardiac 18F-FDG uptake was lower in patients receiving bezafibrate and levothyroxine and higher in patients receiving benzodiazepines. If further confirmed by prospectively designed studies, manipulation of these drugs may represent tools for optimized PET/CT imaging. ER -