RT Journal Article SR Electronic T1 PET/CT Quantitation of the Effect of Patient-Related Factors on Cardiac 18F-FDG Uptake JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 234 OP 239 VO 48 IS 2 A1 Israel, Ora A1 Weiler-Sagie, Michal A1 Rispler, Shmuel A1 Bar-Shalom, Rachel A1 Frenkel, Alex A1 Keidar, Zohar A1 Bar-Shalev, Avi A1 Strauss, H. William YR 2007 UL http://jnm.snmjournals.org/content/48/2/234.abstract AB The effect of multiple patient-related factors on the degree of cardiac 18F-FDG uptake was assessed. Methods: Five hundred four consecutive patients undergoing routine 18F-FDG PET/CT studies completed a clinical questionnaire. 18F-FDG uptake was measured as the mean standardized uptake value within the heart delineated on the CT component of the study. Univariate and multivariate analyses assessed the influence of 51 clinical factors on cardiac 18F-FDG uptake. Results: On both multivariate and univariate analyses, cardiac 18F-FDG uptake was significantly lower in diabetics and in patients receiving bezafibrate or levothyroxine. Cardiac 18F-FDG uptake was significantly higher in men, patients younger than 30 y old, fasting duration of <5 h, patients with heart failure, and those receiving benzodiazepines. Conclusion: Cardiac 18F-FDG uptake was lower in patients receiving bezafibrate and levothyroxine and higher in patients receiving benzodiazepines. If further confirmed by prospectively designed studies, manipulation of these drugs may represent tools for optimized PET/CT imaging.