PT - JOURNAL ARTICLE AU - Israel, Ora AU - Weiler-Sagie, Michal AU - Rispler, Shmuel AU - Bar-Shalom, Rachel AU - Frenkel, Alex AU - Keidar, Zohar AU - Bar-Shalev, Avi AU - Strauss, H. William TI - PET/CT Quantitation of the Effect of Patient-Related Factors on Cardiac <sup>18</sup>F-FDG Uptake DP - 2007 Feb 01 TA - Journal of Nuclear Medicine PG - 234--239 VI - 48 IP - 2 4099 - http://jnm.snmjournals.org/content/48/2/234.short 4100 - http://jnm.snmjournals.org/content/48/2/234.full SO - J Nucl Med2007 Feb 01; 48 AB - The effect of multiple patient-related factors on the degree of cardiac 18F-FDG uptake was assessed. Methods: Five hundred four consecutive patients undergoing routine 18F-FDG PET/CT studies completed a clinical questionnaire. 18F-FDG uptake was measured as the mean standardized uptake value within the heart delineated on the CT component of the study. Univariate and multivariate analyses assessed the influence of 51 clinical factors on cardiac 18F-FDG uptake. Results: On both multivariate and univariate analyses, cardiac 18F-FDG uptake was significantly lower in diabetics and in patients receiving bezafibrate or levothyroxine. Cardiac 18F-FDG uptake was significantly higher in men, patients younger than 30 y old, fasting duration of &lt;5 h, patients with heart failure, and those receiving benzodiazepines. Conclusion: Cardiac 18F-FDG uptake was lower in patients receiving bezafibrate and levothyroxine and higher in patients receiving benzodiazepines. If further confirmed by prospectively designed studies, manipulation of these drugs may represent tools for optimized PET/CT imaging.