RT Journal Article
SR Electronic
T1 Dosimetry in Peptide Radionuclide Receptor Therapy: A Review
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1467
OP 1475
VO 47
IS 9
A1 Cremonesi, Marta
A1 Ferrari, Mahila
A1 Bodei, Lisa
A1 Tosi, Giampiero
A1 Paganelli, Giovanni
YR 2006
UL http://jnm.snmjournals.org/content/47/9/1467.abstract
AB The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.