TY - JOUR T1 - Dual Time Point <sup>18</sup>F-FDG PET Imaging Detects Breast Cancer with High Sensitivity and Correlates Well with Histologic Subtypes JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1440 LP - 1446 VL - 47 IS - 9 AU - Ayse Mavi AU - Muammer Urhan AU - Jian Q. Yu AU - Hongming Zhuang AU - Mohamed Houseni AU - Tevfik F. Cermik AU - Dhurairaj Thiruvenkatasamy AU - Brian Czerniecki AU - Mitchell Schnall AU - Abass Alavi Y1 - 2006/09/01 UR - http://jnm.snmjournals.org/content/47/9/1440.abstract N2 - This prospective study was designed to assess the utility of the dual time point imaging technique by 18F-FDG PET in detecting primary breast cancer and to determine whether there is a relationship between 18F-FDG uptake and its change over time and the histopathologic subtypes. Methods: One hundred fifty-two patients with newly diagnosed breast cancer underwent 2 sequential PET scans (dual time point imaging) for preoperative staging. The maximum standardized uptake value (SUVmax) of 18F-FDG was measured from both time points. The percent change in SUVmax (Δ%SUVmax) between time points 1 (SUVmax1) and 2 (SUVmax2) was calculated. Patients were divided into 2 groups according to histopathology as invasive and noninvasive. Invasive tumors were also divided into 2 groups (&gt;10 mm and 4−10 mm). The tumor-to-contralateral normal breast (background) ratios of SUVmax at both time points for groups were measured and the Δ%SUVmax values were calculated. Results: The mean ± SD of the SUVmax1, the SUVmax2, and the Δ%SUVmax were 3.9 ± 3.7, 4.3 ± 4.0, and 8.3% ± 11.5% for invasive; 2.0 ± 0.6, 2.1 ± 0.6, and 3.4% ± 13.0% for noninvasive; and were 1.2 ± 0.3, 1.1 ± 0.2, and –10.0% ± 10.8% for the contralateral normal breast groups, respectively. In the comparison of SUVmax1, Δ%SUVmax, and the tumor-to-background ratios among groups, all results were significant (P &lt; 0.001). Visual assessment revealed that the sensitivity of dual time point imaging was 90.1% for invasive cancer &gt;10 mm, 82.7% for invasive breast cancers 4−10 mm, and 76.9% for noninvasive breast cancers. Conclusion: Dual time point imaging is a simple and noninvasive method that may improve the sensitivity and accuracy of 18F-FDG PET in assessing patients with primary breast cancer. The changes that are noted in SUVs in dual time point imaging vary depending on the histopathologic type of primary breast cancer. ER -