PT  - JOURNAL ARTICLE
AU  - Siegrist, Patrick T.
AU  - Gaemperli, Oliver
AU  - Koepfli, Pascal
AU  - Schepis, Tiziano
AU  - Namdar, Mehdi
AU  - Valenta, Ines
AU  - Aiello, Floreana
AU  - Fleischmann, Samuel
AU  - Alkadhi, Hatem
AU  - Kaufmann, Philipp A.
TI  - Repeatability of Cold Pressor Test–Induced Flow Increase Assessed with H<sub>2</sub><sup>15</sup>O and PET
DP  - 2006 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1420--1426
VI  - 47
IP  - 9
4099  - http://jnm.snmjournals.org/content/47/9/1420.short
4100  - http://jnm.snmjournals.org/content/47/9/1420.full
SO  - J Nucl Med2006 Sep 01; 47
AB  - The aim of this study was to evaluate the repeatability of endothelium-related myocardial blood flow (MBF) responses to cold pressor testing (CPT) as assessed by PET. Methods: In 10 age-matched control subjects (26.6 ± 3.4 y) and 10 tobacco smokers (24.9 ± 3.3 y) MBF was assessed at rest and after repeated CPT (CPT1 and CPT2, 40 min apart) using PET with H215O. CPT was performed by a 2-min immersion of the subject's foot in ice water. MBF values were corrected for cardiac workload (rate·pressure product), and the repeatability of CPT-related MBF values was assessed according to Bland and Altman. Results: Corrected MBF at CPT1 and CPT2 were comparable in control subjects (1.79 ± 0.37 vs. 1.70 ± 0.35 mL/min/g; P = not significant [NS]) and in smokers (1.97 ± 0.42 vs. 1.80 ± 0.41 mL/min/g; P = NS). Repeatability coefficients in control subjects and smokers were 0.46 mL/min/g (27% of the mean MBF) and 0.51 mL/min/g (27%), respectively. MBF increased significantly after CPT in both groups but tended to be lower in smokers (P = 0.08). Conclusion: PET measured MBF combined with CPT is a feasible and repeatable method for the evaluation of endothelium-related changes of MBF.