PT  - JOURNAL ARTICLE
AU  - Timmers, Henri J.L.M.
AU  - Carrasquillo, Jorge A.
AU  - Whatley, Millie
AU  - Eisenhofer, Graeme
AU  - Chen, Clara C.
AU  - Ling, Alexander
AU  - Linehan, W. Marston
AU  - Pinto, Peter A.
AU  - Adams, Karen T.
AU  - Pacak, Karel
TI  - Usefulness of Standardized Uptake Values for Distinguishing Adrenal Glands with Pheochromocytoma from Normal Adrenal Glands by Use of 6-<sup>18</sup>F-Fluorodopamine PET
AID  - 10.2967/jnumed.107.043281
DP  - 2007 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1940--1944
VI  - 48
IP  - 12
4099  - http://jnm.snmjournals.org/content/48/12/1940.short
4100  - http://jnm.snmjournals.org/content/48/12/1940.full
SO  - J Nucl Med2007 Dec 01; 48
AB  - 6-18F-Fluorodopamine (18F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake. Methods: 18F-FDA PET with CT coregistration was performed in 14 patients (10 men and 4 women; age [mean ± SD], 42.9 ± 13.3 y) with unilateral adrenal gland PHEO and in 13 control subjects (5 men and 8 women; age, 51.7 ± 12.5 y) without PHEO. Standardized uptake values (SUVs) were compared between adrenal glands with PHEO and normal left adrenal glands in control subjects. Results: 18F-FDA accumulation was observed in all adrenal glands with PHEO and in 6 of 13 control adrenal glands (P = 0.02). The SUV was higher in adrenal glands with PHEO (mean ± SD, 16.1 ± 6.1) than in 18F-FDA–positive control adrenal glands (7.7 ± 1.4) (P = 0.005). SUV cutoffs for distinguishing between adrenal glands with PHEO and normal adrenal glands were 7.3 (100% sensitivity) and 10.1 (100% specificity). Conclusion: The SUVs of adrenal foci on 18F-FDA PET facilitate the distinction between adrenal glands with PHEO and normal adrenal glands.