RT Journal Article
SR Electronic
T1 An Implantable Synthetic SPECT Lesion: A Bridge from Phantom to Reality
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1796
OP 1799
DO 10.2967/jnumed.107.046037
VO 48
IS 11
A1 M. Bret Abbott
A1 Lars R. Furenlid
A1 Don W. Wilson
A1 Gail D. Stevenson
A1 James M. Woolfenden
A1 Harrison H. Barrett
YR 2007
UL http://jnm.snmjournals.org/content/48/11/1796.abstract
AB Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. Methods: Anion-exchange columns with bed volumes of 100–300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. Results: Activity of 7.4–22.2 MBq (0.2–0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. Conclusion: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.