RT Journal Article SR Electronic T1 Localization of Dystonic Muscles with 18F-FDG PET/CT in Idiopathic Cervical Dystonia JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1790 OP 1795 DO 10.2967/jnumed.107.044024 VO 48 IS 11 A1 Duk Hyun Sung A1 Joon Young Choi A1 Du-Hwan Kim A1 Eun-Sang Kim A1 Young-Ik Son A1 Young-Seok Cho A1 Su Jin Lee A1 Kyung-Han Lee A1 Byung-Tae Kim YR 2007 UL http://jnm.snmjournals.org/content/48/11/1790.abstract AB The purpose of this study was to investigate whether 18F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles. Methods: Six patients with ICD underwent 18F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased 18F-FDG uptake. Results: Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during 18F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/CT and who were clinically monitored. Conclusion: 18F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD.