PT  - JOURNAL ARTICLE
AU  - Sung, Duk Hyun
AU  - Choi, Joon Young
AU  - Kim, Du-Hwan
AU  - Kim, Eun-Sang
AU  - Son, Young-Ik
AU  - Cho, Young-Seok
AU  - Lee, Su Jin
AU  - Lee, Kyung-Han
AU  - Kim, Byung-Tae
TI  - Localization of Dystonic Muscles with <sup>18</sup>F-FDG PET/CT in Idiopathic Cervical Dystonia
AID  - 10.2967/jnumed.107.044024
DP  - 2007 Nov 01
TA  - Journal of Nuclear Medicine
PG  - 1790--1795
VI  - 48
IP  - 11
4099  - http://jnm.snmjournals.org/content/48/11/1790.short
4100  - http://jnm.snmjournals.org/content/48/11/1790.full
SO  - J Nucl Med2007 Nov 01; 48
AB  - The purpose of this study was to investigate whether 18F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles. Methods: Six patients with ICD underwent 18F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased 18F-FDG uptake. Results: Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during 18F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/CT and who were clinically monitored. Conclusion: 18F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD.