RT Journal Article
SR Electronic
T1 The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer: Long-Term Results of a Longitudinal Cohort Study
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1620
OP 1625
DO 10.2967/jnumed.107.042192
VO 48
IS 10
A1 Martin A. Walter
A1 Christian P. Turtschi
A1 Christian Schindler
A1 Peter Minnig
A1 Jan Müller-Brand
A1 Beat Müller
YR 2007
UL http://jnm.snmjournals.org/content/48/10/1620.abstract
AB The long-term dental safety profile of high-dose radioiodine therapy remained elusive despite more than 6 decades of clinical use. Methods: In a cohort study, we investigated the incidence of sialadenitis, xerostomia, caries, and tooth extractions after high-dose radioiodine therapy for differentiated thyroid cancer and explored risk factors by multiple regression models. Results: One hundred seventy-six participants were recruited (median follow-up, 6.6 y; range, 1.1–32.6 y; patient-years: 8,472 before and 1,421 after radioiodine therapy). Scintigraphic salivary gland uptake during radioiodine treatment predicted development of sialadenitis (odds ratio: 1.31 [1.05–1.63], P = 0.015) and xerostomia (odds ratio: 1.58 [1.16–2.16], P = 0.004). The caries risk increased by postradioiodine xerostomia (% increase: 98.8 [26.5–212], P = 0.003). The long-term risk for postradioiodine tooth extractions increased with increasing cumulative radioiodine activities (% increase [per gigabequerel]: 8.14 [1.07, 15.7], P = 0.02). Conclusion: High-dose radioiodine treatment can impair the long-term dental health, depending on the cumulative radioiodine activity and individual salivary gland radioiodine uptake.