PT - JOURNAL ARTICLE AU - Martin A. Walter AU - Christian P. Turtschi AU - Christian Schindler AU - Peter Minnig AU - Jan Müller-Brand AU - Beat Müller TI - The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer: Long-Term Results of a Longitudinal Cohort Study AID - 10.2967/jnumed.107.042192 DP - 2007 Oct 01 TA - Journal of Nuclear Medicine PG - 1620--1625 VI - 48 IP - 10 4099 - http://jnm.snmjournals.org/content/48/10/1620.short 4100 - http://jnm.snmjournals.org/content/48/10/1620.full SO - J Nucl Med2007 Oct 01; 48 AB - The long-term dental safety profile of high-dose radioiodine therapy remained elusive despite more than 6 decades of clinical use. Methods: In a cohort study, we investigated the incidence of sialadenitis, xerostomia, caries, and tooth extractions after high-dose radioiodine therapy for differentiated thyroid cancer and explored risk factors by multiple regression models. Results: One hundred seventy-six participants were recruited (median follow-up, 6.6 y; range, 1.1–32.6 y; patient-years: 8,472 before and 1,421 after radioiodine therapy). Scintigraphic salivary gland uptake during radioiodine treatment predicted development of sialadenitis (odds ratio: 1.31 [1.05–1.63], P = 0.015) and xerostomia (odds ratio: 1.58 [1.16–2.16], P = 0.004). The caries risk increased by postradioiodine xerostomia (% increase: 98.8 [26.5–212], P = 0.003). The long-term risk for postradioiodine tooth extractions increased with increasing cumulative radioiodine activities (% increase [per gigabequerel]: 8.14 [1.07, 15.7], P = 0.02). Conclusion: High-dose radioiodine treatment can impair the long-term dental health, depending on the cumulative radioiodine activity and individual salivary gland radioiodine uptake.