PT - JOURNAL ARTICLE AU - Bernd J. Pichler AU - Martin S. Judenhofer AU - Ciprian Catana AU - Jeffrey H. Walton AU - Manfred Kneilling AU - Robert E. Nutt AU - Stefan B. Siegel AU - Claus D. Claussen AU - Simon R. Cherry TI - Performance Test of an LSO-APD Detector in a 7-T MRI Scanner for Simultaneous PET/MRI DP - 2006 Apr 01 TA - Journal of Nuclear Medicine PG - 639--647 VI - 47 IP - 4 4099 - http://jnm.snmjournals.org/content/47/4/639.short 4100 - http://jnm.snmjournals.org/content/47/4/639.full SO - J Nucl Med2006 Apr 01; 47 AB - PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 × 10 lutetium oxyorthosilicate crystal arrays and 3 × 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.