RT Journal Article
SR Electronic
T1 Correlation of Hypoxic Cell Fraction and Angiogenesis with Glucose Metabolic Rate in Gliomas Using <sup>18</sup>F-Fluoromisonidazole, <sup>18</sup>F-FDG PET, and Immunohistochemical Studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 410
OP 418
VO 47
IS 3
A1 Lawrence M. Cher
A1 Carmel Murone
A1 Nathan Lawrentschuk
A1 Shanker Ramdave
A1 Anthony Papenfuss
A1 Anthony Hannah
A1 Graeme J. O'Keefe
A1 John I. Sachinidis
A1 Salvatore U. Berlangieri
A1 Gavin Fabinyi
A1 Andrew M. Scott
YR 2006
UL http://jnm.snmjournals.org/content/47/3/410.abstract
AB PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy in staging tumors and potentially in monitoring treatment response. The aim of this study was to evaluate newly diagnosed primary brain tumors for the presence of hypoxia, as indicated by the uptake of 18F-fluoromisonidazole (18F-FMISO) and to examine the relationship of hypoxia to the uptake of 18F-FDG and molecular markers of hypoxia. Methods: Seventeen patients with suspected primary glioma were enrolled prospectively in this study. Sixteen patients had histology, with 2 having metastatic disease. All patients had PET studies with 18F-FMISO and 18F-FDG and MRI studies. Immunohistochemistry was undertaken with tumor markers of angiogenesis and hypoxia. Patients were monitored for disease progression and statistical analysis of data was performed. Results: Of the 14 patients with histology, 8 died with a median time of 16 mo (range, 2−30 mo) until death. Of those who died, 7 had positive and 1 had negative 18F-FMISO uptake. 18F-FMISO uptake was observed in all high-grade gliomas but not in low-grade gliomas. A significant relationship was found between 18F-FDG or 18F-FMISO uptake and expression of VEGF-R1 and Ki67 expression. Other immunohistochemical markers demonstrated a trend toward increased uptake but none was significant. Conclusion: 18F-FMISO PET provides a noninvasive assessment of hypoxia in glioma and was prognostic for treatment outcomes in the majority of patients.18F-FMISO PET may have a role not only in directing patients toward targeted hypoxic therapies but also in monitoring response to such therapies.