PT  - JOURNAL ARTICLE
AU  - Sylvie Rottey
AU  - Guido Slegers
AU  - Simon Van Belle
AU  - Ingeborg Goethals
AU  - Christophe Van de Wiele
TI  - Sequential <sup>99m</sup>Tc-Hydrazinonicotinamide-Annexin V Imaging for Predicting Response to Chemotherapy
DP  - 2006 Nov 01
TA  - Journal of Nuclear Medicine
PG  - 1813--1818
VI  - 47
IP  - 11
4099  - http://jnm.snmjournals.org/content/47/11/1813.short
4100  - http://jnm.snmjournals.org/content/47/11/1813.full
SO  - J Nucl Med2006 Nov 01; 47
AB  - This study was undertaken to evaluate changes in relative 99mTc-hydrazinonicotinamide (HYNIC)-annexin V tumor uptake over time in patients undergoing chemotherapeutic treatment at baseline and at 5–7 h and 40–44 h after treatment initiation. Imaging results are related to clinical outcomes, as assessed with response evaluation criteria in solid tumors (RECIST). Methods: We prospectively included 20 patients (11 men and 9 women; mean age, 59.8 y; range, 22–75 y) scheduled for chemotherapy (n = 19) or bisphosphonate treatment (n = 1). Curable disease was present in 5 patients. The other patients had metastatic disease and were treated in a palliative setting. Three of the 20 enrolled patients were excluded from analysis: 1 patient ultimately refused the proposed chemotherapy treatment; because of difficulties with the labeling procedure, 1 patient did not receive a pretreatment scan; and 1 patient presented with an allergic reaction (rash and nausea) to the 99mTc-HYNIC-annexin V formulation. The remaining 17 patients underwent 3 scintigraphic scans with 99mTc-HYNIC-annexin V: before treatment and 5–7 h and 40–44 h after treatment initiation. The tumor response was evaluated with RECIST and related to observed changes in the ratios of tumor activity to background activity for the largest known lesion; values exceeding 25% the baseline value on either the 5- to 7-h scan or the 40- to 44-h scan were considered significant. Results: With the proposed sequential imaging protocol and a 25% change threshold, responders to treatment could be separated from nonresponders with a 94% accuracy (16/17 patients). Conclusion: Sequential 99mTc-HYNIC-annexin V imaging may allow for assessment of the response to chemotherapy within 3 d after treatment initiation.