RT Journal Article
SR Electronic
T1 Whole-Body Biodistribution and Estimation of Radiation-Absorbed Doses of the Dopamine D<sub>1</sub> Receptor Radioligand <sup>11</sup>C-NNC 112 in Humans
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 100
OP 104
VO 47
IS 1
A1 Vanessa L. Cropley
A1 Masahiro Fujita
A1 John L. Musachio
A1 Jinsoo Hong
A1 Subroto Ghose
A1 Janet Sangare
A1 Pradeep J. Nathan
A1 Victor W. Pike
A1 Robert B. Innis
YR 2006
UL http://jnm.snmjournals.org/content/47/1/100.abstract
AB The present study estimated radiation-absorbed doses of the dopamine D1 receptor radioligand [11C]((+)-8-chloro-5-(7-benzofuranyl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine) (NNC 112) in humans, based on dynamic whole-body PET in healthy subjects. Methods: Whole-body PET was performed on 7 subjects after injection of 710 ± 85 MBq of 11C-NNC 112. Fourteen frames were acquired for a total of 120 min in 7 segments of the body. Regions of interest were drawn on compressed planar images of source organs that could be identified. Radiation dose estimates were calculated from organ residence times using the OLINDA 1.0 program. Results: The organs with the highest radiation-absorbed doses were the gallbladder, liver, lungs, kidneys, and urinary bladder wall. Biexponential fitting of mean bladder activity demonstrated that 15% of activity was excreted via the urine. With a 2.4-h voiding interval, the effective dose was 5.7 μSv/MBq (21.1 mrem/mCi). Conclusion: 11C-NNC 112 displays a favorable radiation dose profile in humans and would allow multiple PET examinations per year to be performed on the same subject.