PT - JOURNAL ARTICLE AU - Fangyu Peng AU - Xin Lu AU - James Janisse AU - Otto Muzik AU - Anthony F. Shields TI - PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of <sup>64</sup>CuCl<sub>2</sub> DP - 2006 Oct 01 TA - Journal of Nuclear Medicine PG - 1649--1652 VI - 47 IP - 10 4099 - http://jnm.snmjournals.org/content/47/10/1649.short 4100 - http://jnm.snmjournals.org/content/47/10/1649.full SO - J Nucl Med2006 Oct 01; 47 AB - Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.