%0 Journal Article
%A Fangyu Peng
%A Xin Lu
%A James Janisse
%A Otto Muzik
%A Anthony F. Shields
%T PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2
%D 2006
%J Journal of Nuclear Medicine
%P 1649-1652
%V 47
%N 10
%X Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.
%U https://jnm.snmjournals.org/content/jnumed/47/10/1649.full.pdf