RT Journal Article SR Electronic T1 Parametric Mapping of Binding in Human Brain of D2 Receptor Ligands of Different Affinities JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 964 OP 972 VO 46 IS 6 A1 Thomas Siessmeier A1 Yun Zhou A1 Hans-Georg Buchholz A1 Christian Landvogt A1 Ingo Vernaleken A1 Markus Piel A1 Ralf Schirrmacher A1 Frank Rösch A1 Mathias Schreckenberger A1 Dean F. Wong A1 Paul Cumming A1 Gerhard Gründer A1 Peter Bartenstein YR 2005 UL http://jnm.snmjournals.org/content/46/6/964.abstract AB 11C-Raclopride has been widely used for PET studies of dopamine D2/3 receptors in human brain. The long half-life of 18F may impart advantages to the novel moderate-affinity benzamide 18F-desmethoxyfallypride and its high-affinity congener 18F-fallypride for competition studies and for detection of extrastriatal binding. However, the in vivo kinetics of these compounds and the quantification approaches for parametric mapping of their specific bindings have not been systematically compared. Methods: Dynamic emission recordings of the 3 tracers were obtained in groups of healthy subjects. A conventional model, graphical analysis using metabolite-corrected arterial inputs, and models with reference tissue inputs were used to calculate voxelwise parametric maps of the equilibrium distribution volume (Vd) and the binding potential (BP) of the 3 radioligands in brain. To test for bias, voxelwise kinetic results were compared with those obtained by volume-of-interest (VOI) analysis. Results: The Vd and BP estimates obtained by VOI analysis did not differ from the mean of voxelwise estimates in the same striatal volumes. In striatum, the mean 18F-desmethoxyfallypride BP ranged from 1.9 to 2.5, whereas the mean 11C-raclopride BP ranged from 3 to 4, depending on the method used for calculation. In contrast, the mean BP of 18F-fallypride ranged from 16 to 27 in striatum and could also be readily quantified in the thalamus. Conclusion: Reference tissue methods for the voxelwise calculation of binding parameters are suitable for parametric mapping of the 3 dopamine D2/3 receptor ligands.