RT Journal Article
SR Electronic
T1 Assessment of Liver Tissue After Radiofrequency Ablation: Findings with Different Imaging Procedures
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 520
OP 525
VO 46
IS 3
A1 Gerald Antoch
A1 Florian M. Vogt
A1 Patrick Veit
A1 Lutz S. Freudenberg
A1 Nina Blechschmid
A1 Olaf Dirsch
A1 Andreas Bockisch
A1 Michael Forsting
A1 Jörg F. Debatin
A1 Hilmar Kuehl
YR 2005
UL http://jnm.snmjournals.org/content/46/3/520.abstract
AB Our goal was to assess the typical appearance of normal liver tissue immediately after radiofrequency ablation (RF-ablation) when imaged with contrast-enhanced ultrasound, CT, MRI, 18F-FDG PET, and PET/CT. Methods: Nineteen RF-ablation sessions were performed on nontumorous liver tissue of 10 Göttingen Mini Pigs. CT, ultrasound, MRI, 18F-FDG PET, and PET/CT were performed immediately after the intervention. All imaging procedures were evaluated qualitatively for areas of increased contrast enhancement (morphologic imaging) and regions of elevated tracer uptake (functional imaging). Images were assessed quantitatively by determination of ratios (rp/p) comparing contrast enhancement/tracer uptake in the periphery of the necrosis with contrast enhancement/tracer uptake of normal liver parenchyma. Results: On morphologic imaging, an increase in contrast enhancement surrounding the ablative necrosis was detected in all lesions. Quantification of this area of increased contrast enhancement revealed ratios of rp/p = 1.57 ± 0.2 for CT and rp/p = 1.57 ± 0.19 for MRI. On PET and PET/CT, homogeneous tracer utilization was found surrounding all lesions. There were no areas of a focal or rim-like increase in glucose metabolism. The ratio rp/p was found to be 1.05 ± 0.08 for functional data. Histologic examination revealed pooling of blood in the sinusoids of the lesion’s periphery that was caused by outflow obstruction due to the central necrosis. Conclusion: On morphologic imaging, a rim-like increase of contrast enhancement was found immediately after RF-ablation resembling peripheral hyperperfusion. This area of contrast enhancement may hamper detection of residual tumor. On the basis of homogeneous tracer distribution surrounding the area of necrosis, PET and PET/CT may serve for early assessment of patients after RF-ablation.