RT Journal Article
SR Electronic
T1 <sup>18</sup>F-CPFPX PET Identifies Changes in Cerebral A<sub>1</sub> Adenosine Receptor Density Caused by Glioma Invasion
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 450
OP 454
VO 46
IS 3
A1 Andreas Bauer
A1 Karl-Josef Langen
A1 Hans Bidmon
A1 Marcus H. Holschbach
A1 Simone Weber
A1 Ray A. Olsson
A1 Heinz H. Coenen
A1 Karl Zilles
YR 2005
UL http://jnm.snmjournals.org/content/46/3/450.abstract
AB Adenosine plays a critical role in both tumor proliferation and the cerebral response to tumor invasion. We used 8-cyclopentyl-3-(3-18F-fluoropropyl)-1-propylxanthine (18F-CPFPX) PET to investigate A1 adenosine receptor (A1AR) density as a potential indicator of the local cerebral response to glioma invasion. Methods: A1AR density in F98 glioma–bearing rats was examined by 18F-CPFPX and 3H-CPFPX using PET, quantitative in vitro and ex vivo double-label receptor autoradiography, and immunohistochemical analyses. Results: For all imaging modalities, A1AR signal intensity was increased in a zone surrounding experimental tumors (136%–146% that in control tissue) (P &lt; 0.01). Immunostaining identified activated astrocytes as the main origin of peritumoral A1AR upregulation. The results of a pilot 18F-CPFPX PET study on a patient with recurrent glioblastoma multiforme confirmed increases in A1AR density in the immediate vicinity of the tumor. Conclusion: 18F-CPFPX PET is suitable for the detection of peritumoral changes in A1AR density. Molecular imaging with 18F-CPFPX PET may open novel possibilities for gaining experimental and clinical insights into the cerebral response to tumor invasion.