PT  - JOURNAL ARTICLE
AU  - Marco Brambilla
AU  - Chiara Secco
AU  - Marco Dominietto
AU  - Roberta Matheoud
AU  - Gianmauro Sacchetti
AU  - Eugenio Inglese
TI  - Performance Characteristics Obtained for a New 3-Dimensional Lutetium Oxyorthosilicate–Based Whole-Body PET/CT Scanner with the National Electrical Manufacturers Association NU 2-2001 Standard
DP  - 2005 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 2083--2091
VI  - 46
IP  - 12
4099  - http://jnm.snmjournals.org/content/46/12/2083.short
4100  - http://jnm.snmjournals.org/content/46/12/2083.full
SO  - J Nucl Med2005 Dec 01; 46
AB  - This article reports the results of performance measurements obtained for the lutetium oxyorthosilicate (LSO)–based whole-body PET/CT scanner Biograph 16 HI-REZ with the National Electrical Manufacturers Association (NEMA) NU 2-2001 standard. The Biograph 16 HI-REZ combines a multislice (16-slice) spiral CT scanner with a PET scanner composed of 24.336 LSO crystals arranged in 39 rings. The crystal dimensions are 4.0 × 4.0 × 20 mm3, and the crystals are organized in 13 × 13 blocks coupled to 4 photomultiplier tubes each. The 39 rings allow the acquisition of 81 images 2.0 mm thick, covering an axial field of view of 162 mm. The low- and high-energy thresholds are set to 425 and 650 keV, respectively, acquiring data within a 4.5-ns-wide coincidence window. Methods: Performance measurements for the LSO-based PET/CT scanner were obtained with the NEMA NU 2-2001 standard, taking into account issues deriving from the presence of intrinsic radiation. Results: The results obtained with the NEMA NU 2-2001 standard measurements were as follows: average transverse and axial spatial resolutions (full width at half maximum) at 1 cm and at 10 cm off axis of 4.61 (5.10) mm and 5.34 (5.91) mm, respectively; average sensitivity of 4.92 counts per second per kilobecquerel for the 2 radial positions (0 and 10 cm); 34.1% system scatter fraction; and peak noise equivalent count (NEC) rates of 84.77 kilocounts per second (kcps) at 28.73 kBq/mL (k = 1 in the NEC formula; noiseless random correction) and 58.71 kcps at 21.62 kBq/mL (k = 2; noisy random correction). Conclusion: The new integrated PET/CT system Biograph 16 HI-REZ has good overall performance, with, in particular, a high resolution, a low scatter fraction, and a very good NEC response.