TY - JOUR T1 - Comparison of Changes in Tumor Metabolic Activity and Tumor Size During Chemotherapy of Adenocarcinomas of the Esophagogastric Junction JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2029 LP - 2034 VL - 46 IS - 12 AU - Hinrich A. Wieder AU - Ambros J. Beer AU - Florian Lordick AU - Katja Ott AU - Michael Fischer AU - Ernst J. Rummeny AU - Sibylle Ziegler AU - Jörg R. Siewer AU - Markus Schwaiger AU - Wolfgang A. Weber Y1 - 2005/12/01 UR - http://jnm.snmjournals.org/content/46/12/2029.abstract N2 - We evaluated the temporal relationship between chemotherapy-induced changes in tumor glucose use and tumor size. Methods: Twenty patients with adenocarcinoma of the esophagogastric junction (AEG) were studied by 18F-FDG PET and CT scans before neoadjuvant chemotherapy, 14 d after the initiation of therapy, and 4 wk after the completion of therapy. Results: The relative change in 18F-FDG uptake was more than 2 times larger than the decrease in tumor size at all time points (P < 0.01). At 14 d after the initiation of chemotherapy, there was no correlation between the reduction in 18F-FDG uptake and tumor wall thickness. The change in 18F-FDG uptake after 14 d of therapy was significantly correlated with the reduction in tumor size after the completion of therapy. Conclusion: In AEG, changes in tumor metabolism are a more sensitive parameter for assessing the effects of chemotherapy than are changes in tumor size. Early changes in metabolic activity predict the subsequent reduction in tumor size. ER -