PT - JOURNAL ARTICLE AU - Aliasghar Khorsand AU - Senta Graf AU - Harald Eidherr AU - Wolfgang Wadsak AU - Kurt Kletter AU - Heinz Sochor AU - Ernst Schuster AU - Gerold Porenta TI - Gated Cardiac <sup>13</sup>N-NH<sub>3</sub> PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated <sup>18</sup>F-FDG PET DP - 2005 Dec 01 TA - Journal of Nuclear Medicine PG - 2009--2013 VI - 46 IP - 12 4099 - http://jnm.snmjournals.org/content/46/12/2009.short 4100 - http://jnm.snmjournals.org/content/46/12/2009.full SO - J Nucl Med2005 Dec 01; 46 AB - The purpose of this study was to evaluate myocardial electrocardiography (ECG)-gated 13N-ammonia (13N-NH3) PET for the assessment of cardiac end-diastolic volume (EDV), cardiac end-systolic volume (ESV), left ventricular (LV) myocardial mass (LVMM), and LV ejection fraction (LVEF) with gated 18F-FDG PET as a reference method. Methods: ECG-gated 13N-NH3 and 18F-FDG scans were performed for 27 patients (23 men and 4 women; mean ± SD age, 55 ± 15 y) for the evaluation of myocardial perfusion and viability. For both 13N-NH3 and 18F-FDG studies, a model-based image analysis tool was used to estimate endocardial and epicardial borders of the left ventricle on a set of short-axis images and to calculate values for EDV, ESV, LVEF, and LVMM. Results: The LV volumes determined by 13N-NH3 and 18F-FDG were 108 ± 60 mL and 106 ± 63 mL for ESV and 175 ± 71 mL and 169 ± 73 mL for EDV, respectively. The LVEFs determined by 13N-NH3 and 18F-FDG were 42% ± 13% and 41% ± 13%, respectively. The LVMMs determined by 13N-NH3 and 18F-FDG were 179 ± 40 g and 183 ± 43 g, respectively. All P values were not significant, as determined by paired t tests. A significant correlation was observed between 13N-NH3 imaging and 18F-FDG imaging for the calculation of ESV (r = 0.97, SEE = 14.1, P &lt; 0.0001), EDV (r = 0.98, SEE = 15.4, P &lt; 0.0001), LVEF (r = 0.9, SEE = 5.6, P &lt; 0.0001), and LVMM (r = 0.93, SEE = 15.5, P &lt; 0.0001). Conclusion: Model-based analysis of ECG-gated 13N-NH3 PET images is accurate in determining LV volumes, LVMM, and LVEF. Therefore, ECG-gated 13N-NH3 can be used for the simultaneous assessment of myocardial perfusion, LV geometry, and contractile function.