PT  - JOURNAL ARTICLE
AU  - Hiroshi Yamauchi
AU  - Takashi Kudoh
AU  - Yoshihiko Kishibe
AU  - Jinei Iwasaki
AU  - Shinya Kagawa
TI  - Selective Neuronal Damage and Borderzone Infarction in Carotid Artery Occlusive Disease: A <sup>11</sup>C-Flumazenil PET Study
DP  - 2005 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1973--1979
VI  - 46
IP  - 12
4099  - http://jnm.snmjournals.org/content/46/12/1973.short
4100  - http://jnm.snmjournals.org/content/46/12/1973.full
SO  - J Nucl Med2005 Dec 01; 46
AB  - The pathogenesis of selective neuronal damage in internal carotid artery (ICA) occlusive disease is unclear. Imaging of the central-type benzodiazepine receptor (BZR), which is expressed by most cortical neurons, provides information on the neuronal alterations induced by ischemia in vivo. Hemodynamic ischemia due to ICA occlusive disease may cause not only borderzone infarction but also selective neuronal damage beyond the regions of infarcts, which may be detected by a decrease in BZR in the normal-appearing cerebral cortex. The purpose of this study was to determine whether selective neuronal damage is associated with borderzone infarction in ICA occlusive disease. Methods: We measured BZR using PET and 11C-flumazenil in 62 nondisabled patients with ICA steno-occlusive lesions in the chronic stage. Flumazenil binding potential (BP) was calculated using the dynamic data and the reference tissue model. The infarcts on MRI—which were categorized as territorial, borderzone (external or internal), striatocapsular, lacunar, and other white matter infarcts—were correlated with the mean cerebral/cerebellar cortical BP ratio in the hemisphere with ICA occlusive disease. Results: Patients with borderzone infarction (n = 18) had a significantly decreased flumazenil BP ratio in the hemisphere with ICA occlusive disease compared with patients without borderzone infarction (n = 44) and healthy control subjects (n = 10). Multivariate analysis showed that external borderzone infarction was an independent predictor of the decreased flumazenil BP ratio. Conclusion: In ICA occlusive disease, selective neuronal damage demonstrated as decreased BZR is associated with borderzone infarction, suggesting that hemodynamic ischemia leading to borderzone infarction may cause selective neuronal damage beyond the regions of infarcts in the chronic stage.