RT Journal Article SR Electronic T1 Is Iterative Reconstruction an Alternative to Filtered Backprojection in Routine Processing of Dopamine Transporter SPECT Studies? JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1804 OP 1811 VO 46 IS 11 A1 Walter Koch A1 Christine Hamann A1 Julia Welsch A1 Gabriele Pöpperl A1 Perry E. Radau A1 Klaus Tatsch YR 2005 UL http://jnm.snmjournals.org/content/46/11/1804.abstract AB In general, striatal dopamine transporter (DAT) binding is assessed by use of data reconstructed by filtered backprojection (FBP). The aim of this study was to investigate whether the use of an iterative reconstruction algorithm (ordered-subset expectation maximization [OSEM]) may provide results comparable to or even better than those obtained by standard FBP. Methods: In 50 patients with parkinsonian syndromes, SPECT scans were acquired 4 h after injection of 185 MBq of 123I-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)tropane (123I-FP-CIT) by use of a triple-head γ-camera fitted with low-energy, high-resolution fanbeam collimators. After reconstruction by FBP and OSEM, data were filtered with a Butterworth filter and corrected for attenuation. Patient studies were automatically fitted to a mean template with a corresponding 3-dimensional (3D) volume-of-interest map covering the striatum, caudate, and putamen as well as an occipital reference region to calculate specific DAT binding. In addition, studies with an anthropomorphic 3D striatal phantom were performed to mimic different pathologies. Results: Visual assessment of phantom and patient data suggested a better separation between the caudate and the putamen in studies reconstructed by OSEM than in those reconstructed by FBP. There was an excellent correlation between specific DAT binding assessed by OSEM and that assessed by FBP (R2 values: striatum, 0.999; caudate, 0.998; putamen, 0.998). Mean specific striatal binding obtained by OSEM was approximately 6% lower than that obtained by FBP. In no case was diagnostic information from OSEM inferior to that from FBP. Conclusion: Iterative reconstruction of 123I-FP-CIT SPECT studies for the assessment of DAT is feasible in routine clinical practice. A close correlation between FBP and OSEM data suggested that the latter also allow reliable quantification of DAT binding. Because of a better separation between the caudate and the putamen in the visual evaluation, as suggested by phantom and patient studies, OSEM may even be considered the preferable approach.