RT Journal Article SR Electronic T1 OSEM Reconstruction, Associated with Temporal Fourier and Depth-Dependant Resolution Recovery Filtering, Enhances Results from Sestamibi and 201Tl 16-Interval Gated SPECT JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1789 OP 1795 VO 46 IS 11 A1 Pierre-Yves Marie A1 Wassila Djaballah A1 Philippe R. Franken A1 Chris Vanhove A1 Marc A. Muller A1 Henri Boutley A1 Sylvain Poussier A1 Pierre Olivier A1 Gilles Karcher A1 Alain Bertrand YR 2005 UL http://jnm.snmjournals.org/content/46/11/1789.abstract AB Gated SPECT recorded with 16 intervals determines left ventricular (LV) ejection fraction more accurately than does gated SPECT recorded with 8 intervals but produces higher image noise. This study aimed to assess the results from sestamibi and 201Tl 16-interval gated SPECT when both signal-to-noise ratio and spatial resolution were enhanced with an original method of reconstruction. Methods: Forty patients with coronary artery disease underwent 201Tl and sestamibi 16-interval gated SPECT and, to be used as a reference, cardiac MRI. Assessments of global and regional LV function provided by ordered-subsets expectation maximization (OSEM) with depth-dependant resolution recovery and temporal Fourier filtering were compared with those from conventional filtered backprojection (FBP) previously optimized by screening various filter frequencies and various temporal smoothing levels. Results: For both tracers, LV ejection fraction was determined best when the association of OSEM with depth-dependant resolution recovery was used alone, with temporal Fourier filtering, or with a slight 2-frame temporal smoothing: Mean absolute values of relative errors ranged from 3.2% to 3.6% (4.0%–7.9% for FBP), and coefficient correlation ranged from 0.91 to 0.93 (0.70–0.91 for FBP). Among these 3 reconstruction methods, the association of OSEM with depth-dependant resolution recovery with temporal Fourier filtering provided the highest signal-to-noise ratio, with mean increases of 54% for sestamibi and 80% for 201Tl when compared with FBP, and the best analysis of segmental contractility, with exact agreement rates with MRI being 73% for 201Tl and 79% for sestamibi. Conclusion: OSEM associated with temporal Fourier filtering and depth-dependant resolution recovery filtering enhances the LV function assessment provided by sestamibi and 201Tl 16-interval gated SPECT and dramatically reduces image noise, a property that enhances and facilitates image interpretation.