RT Journal Article
SR Electronic
T1 MIBG and Somatostatin Receptor Analogs in Children: Current Concepts on Diagnostic and Therapeutic Use
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 55S
OP 61S
VO 46
IS 1 suppl
A1 Farzana D. Pashankar
A1 M. Sue O’Dorisio
A1 Yusuf Menda
YR 2005
UL http://jnm.snmjournals.org/content/46/1_suppl/55S.abstract
AB Nuclear imaging techniques such as bone scans, metaiodobenzylguanidine (MIBG) scans, and 111In-diethylenetriaminepentaacetic acid-octreotide scans have greatly increased the sensitivity and specificity of both diagnostic and follow-up protocols for pediatric solid tumors. Molecular targets that are specific for certain pediatric tumors are now being developed. Targets include cell membrane receptors targeted by specific ligands, subcellular organelles targeted by false transmitters, and cellular proteins targeted by antibodies. This review focuses on the use of MIBG (which is a false transmitter) and octreotide (which is a ligand for G protein receptor) in the diagnosis and treatment of solid tumors that affect children and young adults.